Resveratrol Inhibits Myocardial Apoptosis by Regulating the Protein Kinase R-like Endoplasmic Reticulum Kinase Endoplasmic Reticulum Stress Pathway and Improves Myocardial Remodeling and Cardiac Function after Myocardial Infarction

To analyze the effect of resveratrol on myocardial remodeling and cardiac function after infarction by inhibiting cell apoptosis through regulating silent information regulator 1/protein kinase R-like endoplasmic reticulum pathway. 32 healthy male sprague dawley rats were divided into control group (without any treatment), model (ligation left anterior descending branch to establish a model), sham operation without ligation) branch+resveratrol 8 mg/kg/d), each. The changes function, remodeling, pathway related proteins observed 4 w modeling. Left ventricular end-diastolic diameter end-systolic dimension levels in significantly higher than those group, ejection fraction short axis shortening rate lower (p<0.01), (p<0.01). In cells arranged disordered manner fibrogenic hyperplasia occurred, while pathological reduced compared with group. collagen volume tissue was that (p<0.05) (p<0.05). (p<0.01) expression Phosphate-protein R like kinase, Phosphate eukaryotic initiation factor 2 Activating transcription Silent Information Regulator 1 Resveratrol can reduce stress improve rats, providing new target for clinical treatment infarction.